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doi: 10.3390/cells9071642 122 AriozBITarakciogluEOlcumMGencS

The focus is on sustainable fat loss, not just water weight

Together, these primary data delineate a pathogenic axis spanning focal iron accumulation, peripheralcentral iron imbalance, and ferroptosis susceptibility in early AD. Further evidence shows that ferritin levels in cerebrospinal fluid (CSF) can predict the rate of cognitive decline and are significantly associated with both A-positivity on PET imaging and elevated t-Tau concentrations

But this target hasnt been studied much yet

-syn appears to play a role in the translocation of voltage-dependent anion-selective channel 1 (VDAC1) to the outer membrane, leading to mitochondrial damage by potentially depolarizing the mitochondrial membrane, resulting in fragmentation and degradation